Research Chemical API China Probenecid CAS 57-66-9 Used as an Antibiotic Treatment

Basic Info

Model NO.	57-66-9
Colour	White
Common Name	Probenecid
CAS Number	57-66-9
Molecular Weight	285.359
Molecular Formula	C13h19no4s
Boiling Point	438.0±47.0 °c at 760 Mmhg
Flash Point	218.7±29.3 °c
Melting Point	194-196°c
Transport Package	Bag
Specification	25 kg per barrel
Trademark	best
Origin	China
Production Capacity	10000000

Product Description

Product Description.

Chemical & Physical Properties

Density	1.2±0.1 g/cm3
Boiling Point	438.0±47.0 °C at 760 mmHg
Melting Point	194-196°C
Molecular Formula	C13H19NO4S
Molecular Weight	285.359
Flash Point	218.7±29.3 °C
Exact Mass	285.103485
PSA	83.06000
LogP	3.30
Vapour Pressure	0.0±1.1 mmHg at 25°C
Index of Refraction	1.542
Storage condition	Store at RT
Stability	Stable, but may be light sensitive. Incompatible with strong oxidizing agents.
Water Solubility	<0.1 g/100 mL at 20 ºC

Application

Probenecid is a chemically synthetic sulfa anti-gout drug, also known as oxybenzone sulfonamides, which has dual role of both promoting the excretion of uric acid excretion and inhibiting the excretion of penicillin. Clinically it is used for treating chronic gout and suppressing excretion of penicillin-type drugs in order to increase their clinical plasma concentration as an adjuvant drug of penicillin therapy. Its mechanism of action is inhibiting the re-absorption of renal tubular on uric acid, thus increasing uric acid excretion and further lowering plasma uric acid concentration for reducing the deposition of urate in tissues and prevent the crystallization of urate. This product can also promote the dissolution of the pre-formed urate, thereby reducing its damage on the joint. In addition, the product can also competitively inhibit the secretion of a weak organic acid (such as penicillin, cephalosporins) in the renal tubules, which can increase blood concentrations of these antibiotics and prolong their duration of action. This product is easy for oral administration with a plasma protein binding rate of 85% to 90%. Adults take 1 g orally each time with the plasma concentration reaches peak after 2~4 hour and with a half-life of being 6 to 12 hours. Probenecid is rapidly metabolized in the liver with the major metabolite being probenecid acetyl glucuronic acid. The main metabolite is excreted through the urine. This product has no anti-inflammatory and analgesic effect, and thus being invalid for treating acute gout. Acute toxicity test results: orally: LD50 of rats being 1600mg/kg. After the oral administration, the major adverse reactions are gastrointestinal reactions with others adverse reactions including dizziness, headache, facial flushing, urinary frequency, gingival swelling and pain, skin rash; there are also occasional allergic reactions. It is not suitable for being applied to patients of acute gout and with history of uric acid crystal deposition in kidney and ureter. Patients of peptic ulcer or blood abnormalities and pregnant women should take with caution. Patients of renal dysfunction are not allowed for using it.

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Company Profile
Hebei Best Biotechnology is a modern advanced enterprise specializing in production and exportation of APIs,Pharmaceutical intermediates, peptides, plant extracts etc. Our products are widely used in medicine, health care products, cosmetics, nutritional supplements and food additives areas. After years of continuous development,company has been accumulated rich experience in international trade and customer resources, established a stable customer base and perfect marketing service network. In addition, the company has established long-term technical cooperation with experts and professors from many universities and research institutes in the province. Excellent quality, reasonable price, rapid delivery and good service ensure us to satisfy all kinds of your demands. If you are interested in us, please contact me.

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